Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure
Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure
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DOI：
10.1021/ol5026958
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发表时间：
2014-11-07
期刊：
影响因子：
5.2
通讯作者：
Ryu, Ilhyong
中科院分区：
文献类型：
--
作者：
Fukuyama, Takahide;Totoki, Takenori;Ryu, Ilhyong
使用串联的流动微反应器进行了1-硅基取代的有机石硫化物与CO的生成和随后的反应。该流动体系被证明对硅基取代的有机锂硫化物在轻微加压的CO条件下的羰化反应是非常有用的，这是通过使用背压调节器方便地生成的。该流动体系与加热相结合，加速了1-硅基取代的有机锂的羰化反应，使在CO气氛下间歇烧瓶反应中失效的稳定的硅基取代烷基锂1，3-二硅烯丙基锂参与了高效的羰基化反应。
The generation of, and subsequent reactions with, 1-silyl-substituted organolithiums with CO was carried out using serially connected flow microreactors. The flow system proved to be quite useful for the carbonylation of silyl-substituted organolithiums under slightly pressurized conditions of CO, which was created conveniently by the use of a back-pressure regulator. This flow system, coupled with heating, accelerated the carbonylation reaction of 1-silyl-substituted organolithiums and allowed the stable silyl-substituted alkyllithium, 1,3-disilylallyllithium, which was not effective in a batch-flask reaction under a CO atmosphere, to participate in an efficient carbonylation reaction.