Effect of acute exhausting exercise on cytokine gene expression in men.
Effect of acute exhausting exercise on cytokine gene expression in men.
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急性力竭运动对男性细胞因子基因表达的影响。
DOI:
10.1055/s-2007-972850
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发表时间:
1996
期刊:
影响因子:
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通讯作者:
Gause,WL
中科院分区:
文献类型:
--
作者:
Natelson,BH;Zhou,X;Ottenweller,JE;Bergen,MT;Sisto,SA;Drastal,S;Tapp,WN;Gause,WL
Accepted after revision: August 28.1995 m# mm Because of recent interest in the effects of physical exercise on immunologic function, we decided to use state-of-the-art methods to evaluate cytokines in the peripheral blood leukocytes (PBk.) of 7 men before and after a maximal treadmill stress test. Change in cytokine gene expression was quantified from PBk. using a reverse transcriptase polymerase chain reaction assay (RT-PCR). In contrast to reports on serum levels or using In vltro testing. direct gene expression of TNF-a decreased after the stress test (p e0. 008). However, the 47% decrease was relatively small and of questionable biological significance. Levels of IL-la, IL-1 b, IL-2. IL-4, IL-6. IL-10. and 1NF-y did not change.