Psychological and cognitive function: Predictors of adherence with cholesterol lowering treatment
Psychological and cognitive function: Predictors of adherence with cholesterol lowering treatment
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DOI：
10.1207/s15324796abm2702_6
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发表时间：
2004-04-01
影响因子：
3.8
通讯作者：
Dunbar-Jacob, J
中科院分区：
文献类型：
--
作者：
Stilley, CS;Sereika, S;Dunbar-Jacob, J
背景资料。未能坚持药物治疗方案是临床和研究环境中的一个重大问题，但可靠、一致地识别关键的心理社会预测因素仍然难以捉摸。对情绪和人格与坚持相关的研究显示，结果喜忧参半--顺从和客观测量的认知功能在直觉上是相关的，但缺乏经验支持。目的：这项研究是一项二次分析，旨在研究遵循降低血清胆固醇的药物方案与心理和认知功能的几个领域之间的关系。方法：在最初的研究中，参与者在基线时完成了一项人格测量和一系列神经心理学测量；焦虑和抑郁在基线时和每隔4周测量一次。用电子帽监测器跟踪服药依从性24周。结果：在6个月的研究期间，只有23%的样本完全遵守药物治疗方案，至少80%的时间。根据人格五因素理论，责任心和估计智商仍然是分层回归分析中坚持的有力预测因素。抑郁和焦虑、心理灵活性和视觉空间构建能力不那么强健，但在统计学上显著(p<；0.05)与坚持相关。结论：虽然这项分析的结果只解释了坚持的一部分差异，但它们表明了特质、心理和认知因素在坚持研究中的重要性。
Background. Failure to adhere to medication regimes is a significant problem in clinical and research settings yet reliable, consistent identification of key psychosocial predictors remains elusive. Studies of mood and personality related to adherence show mixed results-compliance and objectively measured cognitive function are intuitively related but empirical support is lacking. Purpose: This study is a secondary analysis to examine the relations between adherence with a medication regime for lowering serum cholesterol and several domains of psychological and cognitive functioning. Methods: Participants in the initial study completed a measure of personality and a battery of neuropschological measures at baseline; anxiety and depression were measured at baseline and at 4-week intervals. Medication adherence was tracked with electronic cap monitors for 24 weeks. Results: Only 23% of the sample was fully adherent to medication regimes at least 80% of the, time over the 6-month study period. Conscientiousness, according to the Five Factor Theory of Personality, and estimated IQ remained robust predictors of adherence in hierarchical regression analyses. Depression and anxiety, mental flexibility, and visuospatial-constructional ability were less robust but statistically significant (p < .05) correlates of adherence. Conclusions: Although results of this analysis explain only a portion of the variance in adherence, they demonstrate the importance of trait psychological and cognitive factors in adherence research.