Autofluorescence Imaging Video-Endoscopy System for Diagnosis of Superficial Gastric Neoplasia
Autofluorescence Imaging Video-Endoscopy System for Diagnosis of Superficial Gastric Neoplasia
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自发荧光成像视频内窥镜系统诊断浅表胃肿瘤
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
H. Iishi
中科院分区：
文献类型：
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作者：
N. Uedo;R. Ishihara;H. Iishi
自体荧光成像视频内窥镜系统（AFI）产生实时假彩色图像从计算检测的自体荧光发射的内源性荧光团在粘膜。在胃体的AFI图像中，胃底粘膜呈现紫色，而萎缩的粘膜呈现明亮的绿色。胃肿瘤根据其形态在AFI图像中呈现紫色或绿色，即，分别升高或降低。因此，胃肿瘤的颜色模式分为四种类型：绿色背景中的紫色肿瘤、紫色背景中的紫色肿瘤、绿色背景中的绿色肿瘤和紫色背景中的绿色肿瘤。绿色背景中的紫色肿瘤和紫色背景中的绿色肿瘤容易通过它们的颜色区分。相比之下，紫色背景中的紫色肿瘤很难通过颜色来定义。绿色背景中的绿色肿瘤与周围粘膜颜色相似，但肿瘤的扩展可通过其紫色边缘确定。AFI对肿瘤侵犯的诊断准确率（68%）优于白色光内镜（36%），但不如色素内镜（91%）。低准确率主要是由溃疡或疤痕的干扰引起的，而AFI诊断扁平肿瘤扩展比白色光图像更准确。由于AFI可以显示平坦或等色的肿瘤扩展相比，白色光内镜，它发现了更多的多发性肿瘤患者接受内镜治疗。
An autofluorescence imaging video-endoscopy system (AFI) produces real-time pseudocolor images from computed detection of autofluorescence emitted by endogenous fluorophores in the mucosa. In the AFI images of the gastric body, the fundic mucosa appears purple, whereas atrophic mucosa appear bright green. Gastric tumors appear purple or green in the AFI images according to their morphology, i.e., elevated or depressed, respectively. Therefore, the color patterns of gastric tumors are classified into four types: purple tumors in a green background, purple tumors in a purple background, green tumors in a green background, and green tumors in a purple background. Purple tumors in a green background and green tumors in a purple background are readily distinguished by their color. In contrast, purple tumors in a purple background are difficult to define by color. Green tumors in a green background appear similar in color to the surrounding mucosa, but the tumor extension can be determined by their purple rim. Diagnostic accuracy of AFI for tumor extension was better (68%) than that by white light endoscopy (36%), but was not as good as chromoendoscopy (91%). The low accuracy rate was mainly caused by interference of an ulceration or scar, while the AFI diagnosed flat tumor extension more accurately than did white light images. Because the AFI could visualize flat or isochromatic tumor extension compared with white light endoscopy, it detected more multiple neoplasia in patients who underwent endoscopic treatment.