Mechanisms of Jak/STAT signaling in immunity and disease.
Mechanisms of Jak/STAT signaling in immunity and disease.
复制标题
DOI：
10.4049/jimmunol.1401867
复制
发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
O'Shea JJ
中科院分区：
文献类型：
--
作者：
Villarino AV;Kanno Y;Ferdinand JR;O'Shea JJ
二十多年前，干扰素抗病毒机制的实验导致Janus激酶（JAK）及其下游效应物，激活信号转导（STAT）蛋白的发现。这条通路已经成为膜到核信号传导的范例，并解释了广泛的可溶性因子，包括细胞因子和激素，如何介导其不同的功能。Jak/STAT研究不仅影响了基础科学，特别是在细胞间通讯和基因表达的细胞外部控制方面，而且还成为从实验室到床边过渡的原型，最终发展和临床实施特定途径治疗。这篇简短的综述将综合目前对Jak/STAT生物学的理解，同时总结经验教训和面临的挑战。
More than 2 decades ago, experiments on the antiviral mechanisms of interferons led to the discovery of Janus kinases (JAK) and their downstream effectors, the signal transducer of activation (STAT) proteins. This pathway has since become a paradigm for membrane to nucleus signaling and has come to explain how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene expression, but has also become a prototype for transition from bench to bedside, culminating in the development and clinical implementation of pathway-specific therapeutics. This brief review will synthesize current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.