An Efficient Synthesis of C2-Symmetric Chiral Binaphthyl Ketone Catalysts
An Efficient Synthesis of C2-Symmetric Chiral Binaphthyl Ketone Catalysts
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C2-对称手性联萘酮催化剂的高效合成
DOI：
10.1271/bbb.65.180
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Seki
中科院分区：
文献类型：
--
作者：
T. Furutani;M. Hatsuda;Toshiaki Shimizu;M. Seki
报道了C2对称手性联萘酮1a和B的有效合成方法。该合成的关键特征是Co（salen）催化的外消旋1，1 '-联萘-2，2'-二羧酸单甘酯3a和B的大环内酯化和所得11元环状联萘酚4a和B的脂肪酶催化的对映选择性酰化。
An efficient synthesis of C2-symmetric chiral binaphthyl ketones 1a and b, effective catalysts for asymmetric epoxidation, is reported. The key features of this synthesis are Co(salen)-catalyzed macrolactonization of racemic 1,1'-binaphthyl-2,2'-dicarboxylic acid monoglycidyl esters 3a and b and lipase-catalyzed enantioselective acylation of resulting 11-membered cyclic binaphthyl alcohols 4a and b.