The retinal pigment epithelium is the unique site of transthyretin synthesis in the rat eye.
The retinal pigment epithelium is the unique site of transthyretin synthesis in the rat eye.
复制标题
DOI：
--
复制
发表时间：
1990-03
影响因子：
4.4
通讯作者：
T. Cavallaro;Robert L. Martone;Andrew J. Dwork;Eric A. Schon;Joseph Herbert
中科院分区：
文献类型：
--
作者：
T. Cavallaro;Robert L. Martone;Andrew J. Dwork;Eric A. Schon;Joseph Herbert
甲状腺素运载蛋白（TTR），或前白蛋白，是一个55 kD的四聚体蛋白，在甲状腺素的血浆转运中起重要作用，并通过其与视黄醇结合蛋白的相互作用，视黄醇。在哺乳动物中，TTR合成的四个主要来源已被确定：肝细胞、内脏卵黄囊内胚层、脉络丛上皮和眼睛。我们现在报告原位杂交研究表明，在大鼠眼中，视网膜色素上皮细胞是TTR合成的唯一来源。这一发现强调了脉络丛上皮细胞和视网膜色素上皮细胞之间的发育，结构和功能的同源性。虽然眼部TTR合成的功能意义尚不清楚，但它可能用于运输甲状腺素或视黄醇穿过血视网膜屏障，从而促进其对分化和形态发生的影响。考虑到视黄醇在视觉过程的生物化学中的重要性，我们提出TTR可能在视黄醇的眼内循环中发挥作用。
Transthyretin (TTR), or prealbumin, is a 55-kD tetrameric protein which plays an important role in the plasma transport of thyroxine, and through its interaction with retinol-binding protein, of retinol. Four major sources of TTR synthesis have been identified in the mammal: liver hepatocytes, visceral yolk sac endoderm, choroid plexus epithelium, and the eye. We now report in situ hybridization studies demonstrating that in the rat eye, the retinal pigment epithelium is the unique source of TTR synthesis. This finding underscores the developmental, structural, and functional homology between the choroid plexus epithelium and the retinal pigment epithelium. Although the functional significance of ocular TTR synthesis is unclear, it is likely that it serves to transport thyroxine or retinol across the blood-retina barrier, thereby facilitating their effects on differentiation and morphogenesis. Considering the importance of retinol in the biochemistry of the visual process, we propose that TTR may play a role in the intraocular cycling of retinol.