In vitro cytotoxicity of Ag-Pd-Cu-based casting alloys.
In vitro cytotoxicity of Ag-Pd-Cu-based casting alloys.
复制标题
Ag-Pd-Cu 基铸造合金的体外细胞毒性。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
A. Hensten
中科院分区：
文献类型：
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作者：
L. Niemi;A. Hensten
使用12种Ag-Pd-Cu型合金、一种常规III型金合金和纯Ag、Cu和Pd研究了细胞毒性及其与合金成分、结构、腐蚀以及电偶联的相关性。采用琼脂覆盖细胞培养技术。单相二元CuPd合金只有轻微的细胞毒性低于30重量%的Cu含量。测试的多相合金都是有毒的，但没有毒性和铜含量之间的相关性可以观察到。固溶退火增加了多相合金的细胞毒性。在试验前将单相合金暴露于人工唾液中1周可显著降低其细胞毒性。合金通过外部铜线的电偶联降低了它们的细胞毒性。
The cytotoxicity and its correlation to alloy composition, structure, corrosion, as well as galvanic coupling was studied with 12 Ag-Pd-Cu-type alloys, one conventional type III gold alloy and pure Ag, Cu, and Pd. The agar overlay cell culture technique was used. Single phase binary CuPd alloys were only slightly cytotoxic below a Cu content of 30 wt%. The tested multiphase alloys were all toxic, but no correlation between toxicity and Cu content could be observed. Solid solution annealing increased the cytotoxicity of a multiphase alloy. Exposure of a single phase alloy to an artificial saliva for 1 week prior to the test decreased its cytotoxicity significantly. Galvanic coupling of the alloys through an outer copper wire decreased their cytotoxicity.