Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis.
Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis.
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DOI：
10.4049/jimmunol.1600813
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发表时间：
2016-10-01
期刊：
影响因子：
--
通讯作者：
Hamerman JA
中科院分区：
文献类型：
--
作者：
Buechler MB;Akilesh HM;Hamerman JA
During infection, recognition of pathogens and inflammatory cytokines skews hematopoiesis towards myeloid development, though the precise mechanisms responsible for this are unclear. Here, we show that accelerated myeloid differentiation, known as emergency myelopoiesis, involves recognition of pathogen associated molecular patterns by the common myeloid progenitor (CMP) and is dependent upon type I IFN for monocyte/macrophage differentiation. Direct sensing of Toll-like receptor (TLR) agonists by CMP induced rapid proliferation and induction of myeloid-differentiation genes. Lack of type I IFN signaling in CMP abrogated macrophage differentiation in response to TLR stimuli, whereas exogenous type I IFN amplified this process. Mechanistically, TLR7 induced PI3K/mTOR signaling in CMP, which was enhanced by type I IFN, and this pathway was essential for emergency myelopoiesis. This work identifies a novel mechanism by which TLR and type I IFN synergize to promote monocyte/macrophage development from hematopoietic progenitors, a process critical in triggering rapid immune responses during infection.
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影响因子：
100.3
作者：
Trumpp, Andreas;Essers, Marieke;Wilson, Anne
通讯作者：
Wilson, Anne
DOI：
10.4049/jimmunol.1501231
发表时间：
2015-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Liu A;Wang Y;Ding Y;Baez I;Payne KJ;Borghesi L
通讯作者：
Borghesi L
影响因子：
20.3
作者：
de Bruin, Alexander M.;Libregts, Sten F.;Nolte, Martijn A.
通讯作者：
Nolte, Martijn A.
影响因子：
11.4
作者：
De Luca, K.;Frances-Duvert, V.;Defrance, T.
通讯作者：
Defrance, T.
影响因子：
20.3
作者：
Buitenhuis, Miranda;Verhagen, Liesbeth P.;Coffer, Paul J.
通讯作者：
Coffer, Paul J.