Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology.
Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology.
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DOI：
10.1016/j.jaac.2015.02.006
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发表时间：
2015-05
影响因子：
13.3
通讯作者：
Collishaw, Stephan
中科院分区：
文献类型：
--
作者：
Hammerton, Gemma;Zammit, Stanley;Mahedy, Liam;Pearson, Rebecca M.;Sellers, Ruth;Thapar, Anita;Collishaw, Stephan
患有抑郁症的母亲的后代是发展自杀相关行为的高风险群体。因此，这些后代是预防性干预的优先事项;然而，导致风险的途径，包括后代精神病理学的特定方面，仍不清楚。本研究的目的是探讨是否子女的症状，重性抑郁症（MDD），广泛性焦虑症（GAD），破坏性行为障碍（DBD），注意力缺陷多动障碍（ADHD），酒精滥用独立介导之间的关联母亲抑郁症和子女自杀相关行为。数据来自一个基于人群的出生队列，雅芳父母和儿童纵向研究（ALSPAC）。在母亲的孩子生命的前11年中，确定了三种不同的抑郁症状（轻微，中度，慢性-重度）。在15岁时评估后代的精神病理学，并在16岁时评估自杀相关行为。采用结构方程模型对数据进行分析。有证据表明，与有轻微症状的母亲的后代相比，有慢性重度抑郁症状的母亲的后代自杀意念的风险增加（比值比= 3.04，95%CI = 2.19，4.21）。这种关联是由后代MDD、GAD和DBD症状独立介导的。随着时间的推移，在患有中度抑郁症状的母亲的后代中发现了相同的机制。除了通过后代ADHD症状间接影响的额外证据外，后代自杀企图的结果相似。研究结果强调，抑郁症母亲的后代的自杀预防工作不仅应该针对MDD的后代，考虑其他形式的精神病理学的后代也很重要。
Offspring of mothers with depression are a high-risk group for the development of suicide-related behavior. These offspring are therefore a priority for preventive interventions; however, pathways contributing to risk, including specific aspects of offspring psychopathology, remain unclear. The aim of this study was to examine whether offspring symptoms of major depressive disorder (MDD), generalized anxiety disorder (GAD), disruptive behavior disorder (DBD), attention-deficit/hyperactivity disorder (ADHD), and alcohol abuse independently mediate the association between maternal depression and offspring suicide-related behavior. Data were used from a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Three distinct classes of depression symptoms across the mothers’ first 11 years of their child’s life were identified (minimal, moderate, chronic-severe). Offspring psychopathology was assessed at age 15 years and suicide-related behavior at age 16 years. Data were analyzed using structural equation modeling. There was evidence for increased risk of suicidal ideation in offspring of mothers with chronic-severe depression symptoms in comparison to offspring of mothers with minimal symptoms (odds ratio = 3.04, 95% CI = 2.19, 4.21). This association was independently mediated by offspring MDD, GAD, and DBD symptoms. The same mechanisms were found for offspring of mothers with moderate depression symptoms over time. Results were similar for offspring suicide attempt except for additional evidence of an indirect effect through offspring ADHD symptoms. Findings highlight that suicide prevention efforts in offspring of mothers with depression should not only be targeted at offspring with MDD; it is also important to consider offspring with other forms of psychopathology.
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DOI：
10.1136/bmj.b2393
发表时间：
2009-06-29
期刊：
BMJ (Clinical research ed.)
影响因子：
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作者：
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影响因子：
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通讯作者：
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作者：
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影响因子：
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作者：
Kidger J;Heron J;Lewis G;Evans J;Gunnell D
通讯作者：
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