Neo-osteogenesis of haversian trabeculae through a bone chamber implanted in a rabbit tibial cortex: a control model.
Neo-osteogenesis of haversian trabeculae through a bone chamber implanted in a rabbit tibial cortex: a control model.
复制标题
通过植入兔胫骨皮质的骨室进行哈弗小梁的新骨生成：对照模型。
DOI：
10.1007/bf02555862
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发表时间：
1990
影响因子：
4.2
通讯作者：
Moffat,R
中科院分区：
文献类型：
--
作者：
Winet,H;Bao,JY;Moffat,R
当皮质骨小梁通过并置生长再生为骨室植入物时，观察到皮质骨小梁的新骨生成。从植入后第三周到第八周，每周测量 13 只兔子的骨面积变化。使用活体显微镜进行观察并使用数字图像处理进行分析。图像是计算机捕获的视频帧，相当于 78(6×13) 个单独的观察结果。测量方法是每周用数字化十字准线追踪小梁轮廓，并比较面积变化占圆形视野（“狭缝间隙”）填充的百分比。数据支持以下假设：第 3 周至第 8 周的小梁再生遵循逻辑增长曲线回归：其中 A% 是骨覆盖的狭缝间隙面积的百分比，t 是时间，处于非常高的显着性水平。然而，高度显着的线性回归拟合了数据。统计分析表明，回归线可以拟合植入后第3周至第8周（W3-W8）的骨面积测量结果，给出恒定的新骨生成率7.42±0.67×104μm2/天，并且线性新骨生成率从第4周的73μm/天下降到第8周的21μm/天；后者基于小梁形状的圆段近似。该范围近似于其他工作者报告的皮质间隙缺陷愈合和多孔向内生长愈合范围之间的桥梁，并支持 BCI 控制模型是间隙愈合和多孔向内生长之间的交叉的假设。
Neo-osteogenesis of cortical bone trabeculae was observed as they regenerated into a bone chamber implant by appositional growth. Measures of change in bone area were obtained from 13 rabbits each week starting the third and ending the eighth week postimplantation. Observations were made using intravital microscopy and were analyzed using digital image processing. Images were computer-captured video frames equivalent to 78(6×13) separate observations. They were measured by tracing the trabecular outlines with a digitizing crosshair each week and comparing changes in area as a percent of the circular field-of-view (“slit-gap”) filled. Data supported the hypothesis that trabecular regeneration week 3 to week 8 followed the logistic growth curve regression:where A% is the percent of slit-gap area covered by bone and t is time, at a very high significance level. Nevertheless, a highly significant linear regression fit the data. Statistical analysis showed that the regression line could be fit to bone area measurements from weeks 3 to 8 (W3-W8) postimplantation, giving a constant neo-osteogenesis rate of 7.42±0.67×104μm2/day and a decreasing linear neoosteogenesis rate from 73 μm/day at W4 to 21 μm/day at W8; the latter is based on a circlesegment approximation of trabeculum shape. This range approximated a bridge between ranges for cortical gap defect healing and porous ingrowth healing reported by other workers and supported the hypothesis that the BCI control model was a cross between gap healing and porous ingrowth.