Stem cell paracrine actions and tissue regeneration.
Stem cell paracrine actions and tissue regeneration.
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DOI：
10.2217/rme.09.74
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发表时间：
2010-01
影响因子：
2.7
通讯作者：
McDevitt TC
中科院分区：
文献类型：
--
作者：
Baraniak PR;McDevitt TC
干细胞由于其固有的分化成各种细胞表型的能力而成为再生医学疗法的关键要素，从而提供了许多潜在的细胞疗法来治疗一系列退行性疾病和创伤性损伤。最近出现的一个范式转变表明，干细胞的有益作用可能不仅限于细胞修复，而且还由于其短暂的旁分泌作用。干细胞可以分泌营养因子的有效组合，这些营养因子调节环境的分子组成以引起来自驻留细胞的反应。基于这一新的见解，目前的研究方向包括努力阐明，增强和利用干细胞旁分泌机制的组织再生。本文讨论了现有的研究干/祖细胞营养因子的生产，对组织再生和癌症治疗的影响，以及开发新的战略，使用干细胞旁分泌交付再生医学。
Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to elucidate, augment and harness stem cell paracrine mechanisms for tissue regeneration. This article discusses the existing studies on stem/progenitor cell trophic factor production, implications for tissue regeneration and cancer therapies, and development of novel strategies to use stem cell paracrine delivery for regenerative medicine.