Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK)
Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK)
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DOI：
10.1007/s10529-006-9190-8
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发表时间：
2006-12-01
影响因子：
2.7
通讯作者：
Jeoung, Dooil
中科院分区：
文献类型：
--
作者：
Shim, Hyeeun;Lee, Hansoo;Jeoung, Dooil
癌症相关基因（CAGE）是一种新型癌症/睾丸抗原。它的过度表达会增加粘着斑激酶 (FAK) 的磷酸化并增强 SNU387 细胞的运动性。斑粘附、激酶相关非激酶 (FRNK)（FAK 的内源性抑制剂）被显着抑制。这表明 CAGE 促进的运动需要 FAK。 Rho 相关卷曲螺旋蛋白激酶 (ROCK)（FAK 的激活剂）的抑制也抑制了 CAGE 促进的运动。
The cancer-associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of it increased phosphorylation of focal adhesion kinase (FAK) and enhanced motility of SNU387 cells. Focal adhesion, kinase-related non-kinase (FRNK), an endogenous inhibitor of FAK, was significantly suppressed. This suggests that CAGE-promoted motility requires FAK. The inhibition of Rho-Associated coiled-coil-containing protein kinase (ROCK), an activator of FAK, also suppressed CAGE-promoted motility.