A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
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DOI：
10.1007/3-211-30714-1_35
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发表时间：
2006
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影响因子：
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通讯作者：
H. Uchino;S. Morota;T. Takahashi;Y. Ikeda;Y. Kudo;N. Ishii;B. Siesjö;F. Shibasaki
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文献类型：
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作者：
H. Uchino;S. Morota;T. Takahashi;Y. Ikeda;Y. Kudo;N. Ishii;B. Siesjö;F. Shibasaki
脑缺血导致严重的损伤，表现为迟发性神经元细胞死亡。在我们的研究中，我们表明，新的免疫抑制剂FR 901495在前脑缺血中的显着的神经保护作用不仅是由于抑制钙调磷酸酶，而且还通过亲环素D，脯氨酰顺式/transisomerase家族成员之一，对线粒体通透性转换孔形成引起的线粒体损伤的保护。这些发现为临床应用和开发用于治疗脑以及心脏和肝脏缺血性损伤的新药提供了线索。
Brain ischemia leads to severe damage in the form of delayed neuronal cell death. In our study, we show that the marked neuroprotection of the new immunosuppressant FR901495 in forebrain ischemia is due not only to inhibition of calcineurin, but also to protection against mitochondrial damage caused by mitochondrial permeability transition pore formation through cyclophilin D, one of the prolylcis/transisomerase family members. These findings shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver.