Asymmetric Synthesis of Isotopic Atropisomers based on <i>ortho</i>-CH<sub>3</sub>/CD<sub>3</sub> Discrimination and Their Structural Properties

Asymmetric Synthesis of Isotopic Atropisomers based on <i>ortho</i>-CH<sub>3</sub>/CD<sub>3</sub> Discrimination and Their Structural Properties
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基于<i>ortho</i>-CH<sub>3</sub>/CD<sub>3</sub>判别的同位素阻转异构体的不对称合成及其结构性质

DOI：
10.1021/acs.joc.2c02185
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发表时间：
2022
期刊：
The Journal of Organic Chemistry
影响因子：
--
通讯作者：
Kitagawa Osamu
Kitagawa Osamu
中科院分区：
--
文献类型：
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作者：
Miwa Shota;Senda Ryunosuke;Saito Kazuya;Sato Azusa;Nakamura Yuko;Kitagawa Osamu

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N–C axially chiral 3-(2-trideuteriomethyl-4,6-dimethylphenyl)-2-ethylquinazolin-4-ones and 3-(2-trideuteriomethyl-4,6-dimethylphenyl)-2-(1-phenylpropan-2-yl)quinazolin-4-ones were prepared in high enantio- and diastereomeric purities (98% ee). These quinazolinone derivatives are isotopic atropisomers based onortho-CH3/CD3discrimination and were revealed to possess a slight optical rotation and high rotational stability.