Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkynes
Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkynes
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DOI：
10.1021/ja807952r
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发表时间：
2009-02-04
影响因子：
15
通讯作者：
Matsubara, Seijiro
中科院分区：
文献类型：
--
作者：
Koyama, Ichiro;Kurahashi, Takuya;Matsubara, Seijiro
在镍催化的[4 + 2]环加成反应中，烯酮与炔反应生成多取代吡喃。提出了一个机械原理，这意味着氧杂镍环形成氧化环化镍烯酮，然后插入炔。
A nickel-catalyzed [4 + 2] cycloaddition reaction has been developed where enones react with alkynes to afford polysubstituted pyrans. A mechanistic rationale is proposed, implying oxa-nickela cycle formation by oxidative cyclization of nickel to enone, followed by alkyne insertion.