Sinulariols A-S, 19-oxygenated cembranoids from the Chinese soft coral Sinularia rigida
Sinulariols A-S, 19-oxygenated cembranoids from the Chinese soft coral Sinularia rigida
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DOI：
10.1016/j.tet.2011.06.029
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发表时间：
2011-08-19
期刊：
影响因子：
2.1
通讯作者：
Lin, Wenhan
中科院分区：
文献类型：
--
作者：
Lai, Daowan;Li, Yongxin;Lin, Wenhan
从中国软珊瑚Sinularia rigida中分离得到19个新的西松烷型二萜化合物，命名为Sinulariols A-S（1-19）。它们的结构是在广泛的光谱（2D NMR，IR和MS）分析的基础上结合改进的Mosher方法确定的。所有化合物都具有不寻常的19位含氧官能团，这是西松烷族化合物中罕见的。分离的化合物的生物遗传转化的假设。部分西松烷类化合物表现出明显的防污活性。(C)2011爱思唯尔有限公司保留所有权利。
Chemical examination of a Chinese soft coral Sinularia rigida resulted in the isolation and characterization of 19 new cembrane-type diterpenoids, designated as sinulariols A-S (1-19). Their structures were determined on the basis of extensive spectroscopic (2D NMR, IR, and MS) analysis in association with modified Mosher's method. All compounds featured unusual 19-oxygenated functionalities, which are rarely found from cembranoid family. The biogenetic transformation of the isolated compounds is postulated. Part of the isolated cembranoids showed significant anti-fouling activity. (C) 2011 Elsevier Ltd. All rights reserved.