Achieving probiotic effects via modulating oral microbial ecology.
Achieving probiotic effects via modulating oral microbial ecology.
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DOI：
10.1177/0895937409335626
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发表时间：
2009
影响因子：
--
通讯作者：
Shi W
中科院分区：
文献类型：
--
作者：
He X;Lux R;Kuramitsu HK;Anderson MH;Shi W
与许多病原体是外来入侵者不同，像变形链球菌这样的口腔“病原体”是“正常”口腔微生物区系的一部分。虽然它们表现出某些致病特性，但协同作用和拮抗作用的平衡决定了这些同时存在的病原体是否会造成损害。对这些以微生物生态学为基础的致病机制的认识为疾病治疗和预防提出了新的战略。益生菌是一种潜在有益的活细菌或酵母菌，已被用于抗击龋齿。这包括应用不能产生酸或其他细菌干扰变形链球菌致病作用的变形链球菌类型。虽然这些方法在实验上显示了对变形链球菌的治疗效果，但由于安全和保质期问题，将其转化为商业产品仍然是一个挑战。新的高科技方法，如病原菌的群体感应干扰或靶向抗菌疗法，为实现益生菌防治龋齿的效果提供了新的途径。
Unlike many pathogens are foreign invaders, oral “pathogens” such as Streptococcus mutans are part of the “normal” oral microbial flora. While they express certain pathogenic properties, the balance of synergistic and antagonistic interactions determines whether these çommensal pathogens cause damage or not. Recognition of these microbial ecology based pathogeneses argues for new strategies for disease treatment and prevention. Probiotics, potentially beneficial live bacteria or yeasts, have been used to combat dental caries. This includes the application of S. mutans types that cannot produce acids or other bacteria that interfere with the pathogenic effects of S. mutans. While these approaches show therapeutic effects against S. mutans experimentally, the conversion into commercial products remains a challenge, due to safety and shelf life issues. New high-tech approaches, such as quorum sensing interference of pathogenic bacteria or targeted antimicrobial therapies, offer novel ways to achieve probiotic effects against dental caries.