The Antimicrobial Activity of High-Necrodane and Other Lavender Oils on Methicillin-Sensitive and -Resistant Staphylococcus aureus (MSSA and MRSA)
The Antimicrobial Activity of High-Necrodane and Other Lavender Oils on Methicillin-Sensitive and -Resistant Staphylococcus aureus (MSSA and MRSA)
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DOI：
10.1089/acm.2008.0268
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发表时间：
2009-03-01
影响因子：
2.6
通讯作者：
Buckle, Jane
中科院分区：
文献类型：
--
作者：
Roller, Sibel;Ernest, Nina;Buckle, Jane
目的：本研究的目的是比较几种薰衣草油（单独使用和联合使用）对甲氧西林敏感和耐甲氧西林金黄色葡萄球菌（MSSA 和 MRSA）的抗菌功效。方法：评估了来自薰衣草、宽叶薰衣草、斯多查斯和富含 necrodane 的路易氏乳杆菌的四种化学特征精油的抗菌活性。结果：所有四种薰衣草油均通过直接接触抑制 MSSA 和 MRSA 的生长，但在气相中则不然。油剂量范围为 1 至 20 μL 时，抑制区域的直径范围分别为 8 至 30 mm，显示了剂量响应。在任何单剂量下，无论油的化学成分或所使用的金黄色葡萄球菌菌株如何，抑制程度都非常相似。对几种油的二元组合进行了测试，结果表明，富含 necrodane 的 L. luisieri 油与 L. stoechas（富含 1,8-桉树脑、小茴香酮和樟脑）和 L. langustifolia（富含芳樟醇和乙酸芳樟酯）产生协同作用，产生比单独使用每种油产生的抑制区更大的抑制区。 结论：结果表明，薰衣草油的组合应进一步研究可能用于抗菌产品。
Objective: The objective of this study was to compare the antimicrobial efficacy of several lavender oils, used singly and in combination, on methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA).Methods: Four chemically characterized essential oils from Lavandula angustifolia, L. latifolia, L. stoechas, and a necrodane-rich L. luisieri were assessed for their antibacterial activity using the disc diffusion method.Results: All four lavender oils inhibited growth of both MSSA and MRSA by direct contact but not in the vapor phase. Inhibition zones ranged from 8 to 30 mm in diameter at oil doses ranging from 1 to 20 mu L, respectively, demonstrating a dose response. At any single dose, the extent of inhibition was very similar irrespective of the chemical composition of the oils or the strain of S. aureus used. Several binary combinations of the oils were tested, and the results showed that the necrodane-rich L. luisieri oil interacted synergistically with L. stoechas (high in 1,8-cineole, fenchone, and camphor) and L. langustifolia (rich in linalool and linalyl acetate) to produce larger inhibition zones than those produced using each oil individually.Conclusions: The results suggest that combinations of lavender oils should be investigated further for possible use in antibacterial products.