Behavioral and Neurochemical Differences Between Fischer 344 and Harlan–Wistar Rats Raised Identically
Behavioral and Neurochemical Differences Between Fischer 344 and Harlan–Wistar Rats Raised Identically
复制标题
Fischer 344 和相同饲养的 Harlan-Wistar 大鼠之间的行为和神经化学差异
作者：
A. Rex;J. Voigt;H. Fink
在高架十字迷宫、黑白盒、社交互动测试和改良的旷场测试中对近交费舍尔 344 和远交 Harlan-Wistar 大鼠进行比较，以评估遗传因素对厌恶动机行为的影响。所有使用的动物都是在相同的条件下出生和饲养的。与 Wistar 大鼠相比，Fischer 大鼠在所有测试中都表现出更明显的恐惧行为。在一项单独的微透析研究中，评估了行为变化与生化差异之间的关系，并在高架十字迷宫测试中测量了腹侧海马中的血清素 (5-HT) 释放量。暴露于高架十字迷宫会导致（更焦虑的）Fischer 大鼠海马 5-HT 增加，但不会导致（不太焦虑）Wistar 大鼠的海马 5-HT 增加。结果证实了遗传因素对大鼠情绪的影响，并证明了血清素系统与“焦虑相关”行为之间存在密切（尽管并不简单）的关系。
Inbred Fisher 344 and outbred Harlan–Wistar rats were compared in the elevated plus maze, the black-and-white box, the social interaction test, and a modified open-field test, to assess the contribution of genetic factors to aversion-motivated behavior. All animals used were born and raised under identical conditions. Compared to the Wistar rats, the Fischer rats displayed a more pronounced fearful behavior in all tests. In a separate microdialysis study, the relationship between behavioral variations to biochemical differences was assessed, with serotonin (5-HT) release in the ventral hippocampus being measured during the elevated plus-maze test. Exposure to the elevated plus-maze induced an increase in hippocampal 5-HT in the (more anxious) Fischer rats but not in the (less anxious) Wistar rats. The results confirm the influence of genetic factors on emotionality in rats and demonstrate a close, although not simple, relationship between the serotonergic system and “anxiety-related” behavior.