Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice
Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice
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DOI：
10.1016/j.brainres.2006.11.007
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发表时间：
2007-02-02
期刊：
影响因子：
2.9
通讯作者：
Laviola, Giovanni
中科院分区：
文献类型：
--
作者：
Ognibene, Elisa;Adriani, Walter;Laviola, Giovanni
Reelin是一种细胞外基质蛋白，由GABA能中间神经元分泌，为神经可塑性提供信号。一个下调的reelin可能是一个因素，要考虑在重大精神疾病的研究。因此，杂合子reeler小鼠模型，可能是重要的，以揭示这些行为表型的改变所产生的神经可塑性降低。测试了杂合子（HZ）和野生型（WT）小鼠的焦虑相关行为、运动冲动和吗啡诱导的镇痛。杂合子小鼠在青春期的高架十字迷宫中表现出显著较低水平的焦虑和风险评估相关行为，在一般运动的基础变化的情况下。评估成年小鼠在操作室中的冲动行为概况，HZ小鼠表现出运动冲动水平升高。当在伤害感受测试中评估小鼠时，发现吗啡诱导的镇痛的基因型差异，并且这些结果通过测量中脑中的p-受体得到证实。HZ基因型的基础行为特征揭示了重要的差异，与行为抑制和情绪性的降低一致，这可以早在青春期就被揭示出来，连同冲动行为的轻微增加和疼痛阈值的改变以及成年时。因此，HZ基因型可以代表一个有用的动物模型，用于研究神经可塑性降低导致的行为障碍。(c)2006 Elsevier B. V.保留所有权利。
Reelin is an extracellular matrix protein, secreted by GABAergic interneurons, that provides a signal for neural plasticity. A downregulation of reelin may be a factor to be considered in the study of major psychiatric disorders. The heterozygous reeler mouse model, thus, may be important to reveal those alterations in behavioral phenotype produced by reduced neural plasticity. Heterozygous (HZ) and wild-type (WT) mice were tested for anxiety-related behavior, motor impulsivity, and morphine-induced analgesia. Heterozygous mice showed significantly lower levels of anxiety- and risk-assessment-related behaviors in the elevated plus-maze during adolescence, in the absence of basal changes in general locomotion. Adult mice were assessed for profiles of impulsive behavior in operant chambers, and HZ mice exhibited elevated levels of motor impulsivity. When mice were assessed in nociception tests, a genotype difference in morphine-induced analgesia was found, and these results were confirmed by measurement of p-receptors in the midbrain. The basal behavioral profile of the HZ genotype reveals important differences, consistent with decreased behavioral inhibition and emotionality, which can be revealed as early as in adolescence, together with slight increment of impulsive behavior and altered pain threshold and at the adult age. The HZ genotype can thus represent a useful animal model for the study of behavioral disorders consequent to reduced neural plasticity. (c) 2006 Elsevier B.V. All rights reserved.