A MINIATURE LASER SPECKLE CONTRAST IMAGER FOR MONITORING OF THE NEURO-MODULATORY EFFECT OF TRANSCRANIAL FOCUSED ULTRASOUND STIMULATION.
A MINIATURE LASER SPECKLE CONTRAST IMAGER FOR MONITORING OF THE NEURO-MODULATORY EFFECT OF TRANSCRANIAL FOCUSED ULTRASOUND STIMULATION.
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DOI：
10.1115/dmd2021-1038
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发表时间：
2021-04
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通讯作者：
Y. Zeng;Molly Acord;T. Kaovasia;P. Miao;Junfeng Sun;J. Senarathna;N. Theodore;N. Thakor;A. Manbachi
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作者：
Y. Zeng;Molly Acord;T. Kaovasia;P. Miao;Junfeng Sun;J. Senarathna;N. Theodore;N. Thakor;A. Manbachi
经颅聚焦超声刺激是一种能够刺激或抑制神经网络的神经调节技术。这种神经调节作用使脑部疾病的非侵入性治疗成为可能，例如治疗中风。利用激光散斑对比成像技术在动物实验中监测了脑血流动力学的神经调节作用。然而，成像系统的体积庞大和静止性限制了该成像技术在需要动物有不同体位或清醒的研究中的应用。我们设计了一种结合激光散斑对比成像和经颅聚焦超声刺激的微型显微镜系统，并测试了其在刺激期间监测脑血流动力学的能力，并将结果与台式成像系统进行了比较。
Transcranial focused ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. Such neuro-modulatory effects enable the treatment of brain diseases non-invasively, such as treating stroke. The neuro-modulatory effect on cerebral hemodynamics has been monitored using laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of this imaging technique on research that requires the animal to have different body positions or to be awake. We present the design of a system that combines a miniature microscope for laser speckle contrast imaging and transcranial focused ultrasound stimulation, as well as, test its capability to monitor cerebral hemodynamics during stimulation and compare the result with a benchtop imaging system.