Evaluation of the intravenous magnesium sulfate effect in clinical improvement of patients with acute ischemic stroke
Evaluation of the intravenous magnesium sulfate effect in clinical improvement of patients with acute ischemic stroke
复制标题
DOI：
10.1016/j.clineuro.2012.06.001
复制
发表时间：
2013-04-01
影响因子：
1.9
通讯作者：
Rezaei, Mansour
中科院分区：
文献类型：
--
作者：
Afshari, Daryoush;Moradian, Nasrin;Rezaei, Mansour
背景：越来越多的证据表明，镁可能在中风的发展和中风中和中风后的愈合过程中发挥关键作用。镁是一种N-甲基-D-天冬氨酸(NMDA)谷氨酸受体拮抗剂，已被证明在许多临床前缺血性和兴奋性毒性脑损伤模型中具有神经保护作用。为评价静脉注射硫酸镁对急性缺血性卒中患者的临床改善作用。方法：将107例急性缺血性卒中患者随机分为两组，55例给予硫酸镁4g，15min后给予16g，52例给予相应的安慰剂。研究的主要终点是美国国家卒中研究所(NIHSS)对卒中相关神经功能缺失的评估。结果：接受硫酸镁治疗的患者与接受安慰剂治疗的患者相比有显著的恢复。结论：硫酸镁可作为一种安全有效的神经保护剂用于急性缺血性卒中和腔隙性卒中患者，可能是脑白质生物活性药物的相关和实用的目标人群。(C)2012爱思唯尔B.V.保留所有权利。
Background: Evidence is mounting that magnesium may play a critical role in the development of strokes and the healing process during and after a stroke. Magnesium is an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist that has been shown to be neuroprotective in many preclinical models of ischemic and excitotoxic brain injury. This study was performed to evaluate the intravenous magnesium sulfate effect in clinical improvement of patients with acute ischemic stroke.Methods: One hundred and seven patients with acute ischemic stroke signs and symptoms lasting less than 12 hours were included in the study and were divided into two groups, 55 patients received 4 g of MgSO4 over 15 minutes and then 16 g over the next 24 hours, and 52 patients were received matching placebo. The study primary end point was stroke related neurologic deficit evaluation by the national institute of stroke scale (NIHSS).Results: Patients receiving MgSO4 showed significant recovery compared with the group of patients receiving placebo.Conclusion: This study suggests that magnesium sulfate can be used as a safe and useful neuroprotective agent in acute ischemic stroke and lacunar stroke patients may represent a relevant and practical target population for agents with biological activity in white matter. (c) 2012 Elsevier B.V. All rights reserved.