NTCP and beyond: opening the door to unveil hepatitis B virus entry.
NTCP and beyond: opening the door to unveil hepatitis B virus entry.
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DOI：
10.3390/ijms15022892
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发表时间：
2014-02-19
影响因子：
5.6
通讯作者：
Wakita T
中科院分区：
文献类型：
--
作者：
Watashi K;Urban S;Li W;Wakita T
慢性乙型肝炎病毒（HBV）感染影响着全世界约2.4亿人，是一个重大的公共卫生问题，可增加发生肝硬化和肝细胞癌的风险。鉴于目前的抗hbv药物仅限于基于干扰素的方案和核苷类似物，迫切需要开发新的抗hbv药物。病毒进入过程通常是涉及抗病毒策略的一个有吸引力的靶标。利用人类和belangeri图帕亚的原代细胞以及HepaRG细胞，已经获得了病毒进入的重要决定因素。最近，牛磺胆酸钠共转运多肽（NTCP）被鉴定为HBV进入受体，并建立了一种能够有效支持HBV感染的易感细胞系。这一发现将有助于更深入地了解有效HBV感染的要求，包括阐明分子进入机制。此外，药理学研究表明，NTCP可以作为治疗靶点。本文综述了我们目前对HBV进入机制和NTCP在这一过程中的作用的了解。
Chronic hepatitis B virus (HBV) infection, affecting approximately 240 million people worldwide, is a major public health problem that elevates the risk of developing liver cirrhosis and hepatocellular carcinoma. Given that current anti-HBV drugs are limited to interferon-based regimens and nucleos(t)ide analogs, the development of new anti-HBV agents is urgently needed. The viral entry process is generally an attractive target implicated in antiviral strategies. Using primary cells from humans and Tupaia belangeri, as well as HepaRG cells, important determinants of viral entry have been achieved. Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection. This finding will allow a deeper understanding of the requirements for efficient HBV infection, including the elucidation of the molecular entry mechanism. In addition, pharmacological studies suggest that NTCP is able to serve as a therapeutic target. This article summarizes our current knowledge on the mechanisms of HBV entry and the role of NTCP in this process.
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