Contact-Active Antimicrobial and Potentially Self-Polishing Coatings Based on Cellulose
Contact-Active Antimicrobial and Potentially Self-Polishing Coatings Based on Cellulose
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DOI：
10.1002/mabi.201000306
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发表时间：
2011-01-10
影响因子：
4.6
通讯作者：
Tiller, Joerg C.
中科院分区：
文献类型：
--
作者：
Bieser, Arno M.;Thomann, Yi;Tiller, Joerg C.
描述了一种接触活性抗微生物涂层，其仅在纤维素酶存在下降解，纤维素酶是许多微生物菌株的胞外酶。通过聚合物间隔物将抗微生物DDA接枝到纤维素主链上。研究了涂层的抗菌性、生物降解性和自抛光性能。发现所有涂层对金黄色葡萄球菌具有抗微生物活性。具有高DS和长聚合物间隔物的涂层在水中降解，而具有低DS和短间隔物的涂层即使在纤维素酶的存在下也不水解。一个涂层被发现是选择性降解的纤维素酶和恢复其大部分的抗菌活性后超载和随后的处理与纤维素酶。
A contact-active antimicrobial coating is described that is only degraded in the presence of cellulase, which is an extracellular enzyme of numerous microbial strains. Antimicrobial DDA was grafted to a cellulose backbone via a polymeric spacer. The antimicrobial activity of the coatings, their biodegradability and their self-polishing potential were investigated. It was found that all coatings were antimicrobially active against Staphylococcus aureus. Coatings with high DS and long polymeric spacers degraded in water, while coatings with low DS and short spacers were not hydrolyzed even in the presence of cellulase. One coating was found to be selectively degradable by cellulase and recovered most of its antimicrobial activity after overloading and subsequent treatment with cellulase.