A PATHOLOGICAL STUDY OF SYPHILITIC AORTITIS AND ITS SEROLOGY.
A PATHOLOGICAL STUDY OF SYPHILITIC AORTITIS AND ITS SEROLOGY.
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DOI：
10.1084/jem.23.1.25
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发表时间：
1916-01-01
影响因子：
15.3
通讯作者：
Levy, I J
中科院分区：
文献类型：
--
作者：
Larkin, J H;Levy, I J
1. 梅毒性主动脉炎是一种产生性炎症过程，其最早和最持续的特征是外膜中血管周围圆形细胞浸润。 2. 黄斑性主动脉炎的典型大体图像常常被叠加的弥漫性动脉粥样硬化所掩盖。在早期病例中，主动脉看起来相当正常，仅呈现特征性的组织学变化。 3. 纯粹的主动脉瓣膜不足，除感染性心内膜炎外，总是伴有黄疸。 4.心脏肥大不是黄体主动脉炎的并发症。当出现时，通常与肾炎有关。 5. 即使在梅毒主动脉的晚期标本中，苍白螺旋体的表现也值得怀疑。 6、诊断黄体性主动脉炎应首选采用原Wassermann技术从豚鼠心脏醇提取物制备的抗原。 7. 患有梅毒的患者的补体阳性持续约十五年或更长的时间表明，至少在 80% 至 90% 的病例中，主动脉有可能发生组织学黄体变化。其中 60% 死于主动脉炎。 8. 大约 94% 的主动脉炎患者会出现阳性瓦瑟曼反应。
1. Syphilitic aortitis is a productive inflammatory process, the earliest and most constant feature of which is a perivascular round cell infiltration in the adventitia. 2. The typical gross picture of luetic aortitis is often obscured by a superimposed, diffuse atherosclerosis. In the early cases the aorta appears fairly normal, presenting only the characteristic histological changes. 3. A pure aortic insufficient valve, with the exception of an infectious endocarditis, is always luetic. 4. Cardiac hypertrophy is not a complication of luetic aortitis. When present it is usually associated with a nephritis. 5. The demonstration of Spirochœta pallida, even in advanced specimens of syphilitic aortas, is doubtful. 6. An antigen prepared from alcoholic extract of guinea pig heart with the original Wassermann technique should be preferred in diagnosing luetic aortitis. 7. Positive complement fixations in patients suffering with syphilis for a period of about fifteen years or longer suggest the probability, at least, of histological luetic changes in the aorta in 80 to 90 per cent of the cases. 60 per cent of these die from aortitis. 8. About 94 per cent of patients suffering with aortitis give positive Wassermann reactions.