TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.
TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.
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DOI：
10.1158/0008-5472.can-17-0307
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发表时间：
2017-11-01
期刊：
影响因子：
11.2
通讯作者：
Liu XS
中科院分区：
文献类型：
--
作者：
Li T;Fan J;Wang B;Traugh N;Chen Q;Liu JS;Li B;Liu XS
最近肿瘤免疫治疗的临床成功需要研究肿瘤细胞和宿主免疫系统之间的相互作用。然而，阐明复杂的肿瘤-免疫相互作用面临着主要的计算和实验挑战。在这里，我们提出了肿瘤免疫评估资源(Timer，cistrome.shinyapps.io/Timer)，以全面研究肿瘤与免疫相互作用的分子特征。对32种癌症类型的10,897种肿瘤的6种肿瘤浸润性免疫亚群的水平进行了预先计算。Timer提供了6个主要的分析模块，允许用户交互地探索免疫渗透与一系列因素之间的关联，包括基因表达、临床结果、体细胞突变和体细胞拷贝数变化。Timer提供了一个用户友好的网络界面，用于动态分析和可视化这些关联，这将对癌症研究人员具有广泛的实用价值。
Recent clinical successes of cancer immunotherapy necessitate the investigation of the interaction between malignant cells and the host immune system. However, elucidation of complex tumor-immune interactions presents major computational and experimental challenges. Here we present Tumor Immune Estimation Resource (TIMER, cistrome.shinyapps.io/timer) to comprehensively investigate molecular characterization of tumor-immune interactions. Levels of six tumor-infiltrating immune subsets are pre-calculated for 10,897 tumors from 32 cancer types. TIMER provides 6 major analytic modules that allow users to interactively explore the associations between immune infiltrates and a wide-spectrum of factors, including gene expression, clinical outcomes, somatic mutations, and somatic copy number alterations. TIMER provides a user-friendly web interface for dynamic analysis and visualization of these associations, which will be of broad utilities to cancer researchers.