Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective
Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective
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DOI：
10.1097/01.mcp.0000144502.50149.e0
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Schmid-Grendelmeier, P
中科院分区：
文献类型：
--
作者：
Bisset, LR;Schmid-Grendelmeier, P
综述的目的趋化因子及其受体在过敏性哮喘的发生和维持中的重要性反映在目前致力于这一主题的大量文献中。基于一系列选定的参考文献发表在过去的一年中，这篇评论现在总结了最近的进展，并讨论了可能的影响，这些findings.Recent调查结果特别感兴趣的是报告描述新的趋化因子和嗜酸性粒细胞和肥大细胞之间的相互作用，包括CXCL 5（上皮细胞衍生的嗜酸性粒细胞活化肽-78）和细胞内CCR 3的作用。关于T（H）2细胞优势的新见解在涉及一系列趋化因子的报告中提出，包括CCL 3（MIP-1 α）、GCL 4（MIP-1 β）、CCL 5（RANTES）、CXCL 9（Mig）和CXCL 10（IP-10）。关注嗜酸性粒细胞趋化因子家族（CCL 11、CCL 24和OCL 26）以及CCL 17（TARC）、CCL 22（MDC）、CXCL 9（Mig）和CX（3）CL 1（Fractalkine）的报告强调了结构细胞参与的日益重要性。与金属蛋白酶相关的开创性工作以及专注于蛋白聚糖和β-Arrestin-2的报告也强调了非受体调节机制的发展作用。最后，哮喘遗传性领域的重大进展在与已知基因和新基因相关的报道中得到了体现，包括编码CCR 5和DPP-10的基因。综述趋化因子生物学对过敏性哮喘结局的关键影响在最近的报道中继续得到强调，这些报道描述了嗜酸性粒细胞被招募到肺中并维持局部T（H）2细胞优势的新机制，同样令人感兴趣的是，目前越来越重视结构细胞的参与，非受体调节机制和易感基因的影响。
Purpose of review The importance of chemokines and their receptors to development and maintenance of allergic asthma is reflected in the burgeoning amount of literature currently devoted to this topic. Based on a series of selected references published during the last year, this review now summarizes recent advances and discusses the likely implications of these findings.Recent findings Of particular interest are reports describing novel interactions between chemokines and both eosinophils and mast cells, including a role for CXCL5 (epithelial cell-derived neutrophil-activating peptide-78) and intracellular CCR3. New insights into T(H)2-cell dominance are presented in reports dealing with a range of chemokines, including CCL3 (MIP-1alpha), GCL4 (MIP-1beta), CCL5 (RANTES), CXCL9 (Mig), and CXCL10 (IP-10). The increasing importance of structural cell participation is emphasized by reports focusing on the eotaxin family (CCL11, CCL24, and OCL26), as well as CCL17 (TARC), CCL22 (MDC), CXCL9 (Mig), and CX(3)CL1 (Fractalkine). A developing role for nonreceptor regulatory mechanisms is also emphasized by seminal work relating to metalloproteinases, as well as reports focusing on proteoglycans and beta-Arrestin-2. Finally, significant progress in the field of asthma heritability is featured in reports relating to both known and novel genes, including those encoding CCR5 and DPP-10.Summary The critical influence of chemokine biology on the outcome of allergic asthma continues to be highlighted in recent reports describing novel mechanisms by which eosinophils are recruited into the lung and local T(H)2-cell dominance is maintained, Also of considerable interest is the increasing emphasis currently being realized for structural cell participation, nonreceptor regulatory mechanisms, and the influence of susceptibility genes.