Brucellosis in Sub-Saharan Africa: Current challenges for management, diagnosis and control
Brucellosis in Sub-Saharan Africa: Current challenges for management, diagnosis and control
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DOI：
10.1016/j.actatropica.2015.10.023
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发表时间：
2017-01-01
期刊：
影响因子：
2.7
通讯作者：
Moriyon, I.
中科院分区：
文献类型：
--
作者：
Ducrotoy, M.;Bertu, W. J.;Moriyon, I.
布鲁氏菌病是一种由布鲁氏菌属细菌引起的高度传染性人畜共患病，影响家养和野生哺乳动物。本文讨论了撒哈拉以南非洲（SSA）布鲁氏菌病的细菌学和血清学证据及其流行病学特征。可用于诊断和治疗人类布鲁氏菌病和动物布鲁氏菌病的诊断和控制及其适用性的背景下，SSA和差距确定的工具。这些差距主要涉及对人类布鲁氏菌病更简单和更负担得起的抗菌治疗的需求，B的发展。羊种布氏杆菌病疫苗的研究，该疫苗可以避免目前可用的Rev 1疫苗的缺点，以及骆驼布氏杆菌病和野生动物的血清学诊断试验的研究。还讨论了实施动物疫苗接种的策略。(C)2015年，作者。由爱思唯尔公司出版
Brucellosis is a highly contagious zoonosis caused by bacteria of the genus Brucella and affecting domestic and wild mammals. In this paper, the bacteriological and serological evidence of brucellosis in Sub-Saharan Africa (SSA) and its epidemiological characteristics are discussed. The tools available for the diagnosis and treatment of human brucellosis and for the diagnosis and control of animal brucellosis and their applicability in the context of SSA are presented and gaps identified. These gaps concern mostly the need for simpler and more affordable antimicrobial treatments against human brucellosis, the development of a B. melitensis vaccine that could circumvent the drawbacks of the currently available Rev 1 vaccine, and the investigation of serological diagnostic tests for camel brucellosis and wildlife. Strategies for the implementation of animal vaccination are also discussed. (C) 2015 The Authors. Published by Elsevier B.V.