Oscillating signaling pathways during embryonic development
Oscillating signaling pathways during embryonic development
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DOI：
10.1016/j.ceb.2008.09.002
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发表时间：
2008-12-01
影响因子：
7.5
通讯作者：
Pourquie, Olivier
中科院分区：
文献类型：
--
作者：
Aulehla, Alexander;Pourquie, Olivier
胚胎发育过程中的振荡信号通路活动首先在脊椎动物体节形成过程中被发现。在小鼠中，这一过程被认为在很大程度上由涉及Notch、FGF和Writ途径的循环信号网络控制。令人惊讶的是，最近的几项遗传学研究表明，核心振荡起搏器不太可能涉及这些途径的周期性激活。因此，在体节形成过程中产生振荡基因活性的机制仍有待发现。振荡信号活性最近被确定在发育过程中不同于体节的形成。鸡胚的肢体发育过程和小鼠胚胎神经祖细胞的维持过程都涉及与Notch通路相关的振荡基因活性。这些发现表明，胚胎发育过程中的振荡信号活动可能比以前认为的更普遍。
Oscillatory signaling pathway activity during embryonic development was first identified in the process of vertebrate somite formation. In mouse, this process is thought to be largely controlled by a cyclic signaling network involving the Notch, FGF, and Writ pathways. Surprisingly, several recent genetic studies reveal that the core oscillation pacemaker is unlikely to involve periodic activation by these pathways. The mechanism(s) responsible for the production of oscillatory gene activity during somite formation remains, therefore, to be discovered. Oscillatory signaling activity has recently been identified in developmental processes distinct from somite formation. Both the processes of limb development in chick embryos and the maintenance of neural progenitors in mouse embryos involve oscillatory gene activity related to the Notch pathway. These discoveries indicate that oscillatory signaling activities during embryonic development might serve a more general function than previously thought.