Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?
Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?
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DOI：
10.5230/jgc.2017.17.e1
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发表时间：
2017-03
影响因子：
2.5
通讯作者：
Martins SF
中科院分区：
文献类型：
--
作者：
Macedo F;Ladeira K;Longatto-Filho A;Martins SF
胃癌（GC）由于其侵袭性而具有高死亡率。肿瘤血管生成在胃癌的生长、侵袭和转移扩散中起重要作用。这项工作的目的是审查血管生成的生物标志物相关的GC的行为，在文献中记录。使用MeSH术语检索PubMed数据库：“胃肿瘤/血液[MeSH]或胃肿瘤/血液供应[MeSH]和血管生成蛋白/血液[主要]"。最初共收集了30篇文章，随后排除了4篇。在收集的26篇文献中，16篇研究了血管内皮生长因子（VEGF）的作用，4篇研究了内皮抑素，3篇研究了血管生成素（Ang）-2，2篇研究了Ang-like蛋白2（ANGTPL 2），1篇分别研究了白细胞介素（IL）-12，IL-8和缺氧诱导因子。关于VEGF，6篇文章的结论是该蛋白与淋巴结转移或远处转移有关。5篇文章得出结论，VEGF水平在GC存在时升高，在肿瘤消退后降低，表明VEGF水平可能是复发的预测因子。4篇文章得出结论，高VEGF水平与预后不良和生存率较低相关。Ang-2和ANGTPL 2在GC中升高，并与更侵袭性的疾病相关。内皮抑素与肠GC相关。VEGF是研究最广泛的血管生成因子。它与肿瘤性疾病和淋巴结转移的存在有关。它似乎是疾病进展和缓解的良好生物标志物，但不用于诊断。关于其他生物标志物的数据是不确定的。
Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: “Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]”. A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive.