Sitosterol prevents obesity-related chronic inflammation
Sitosterol prevents obesity-related chronic inflammation
复制标题
DOI：
10.1016/j.bbalip.2017.12.004
复制
发表时间：
2018-02-01
影响因子：
4.8
通讯作者：
Tsukamoto, Kazuhisa
中科院分区：
文献类型：
--
作者：
Kurano, Makoto;Hasegawa, Koji;Tsukamoto, Kazuhisa
植物甾醇在慢性炎症中的生理作用，被认为与代谢性疾病的潜在机制有关，但尚未阐明。因此，在本研究中，我们旨在阐明植物甾醇在临床研究和动物实验中的生理作用。我们观察到糖尿病患者(n=46)和非糖尿病患者(n=178)的血清谷甾醇水平与血清IL-6和肿瘤坏死因子-α水平之间存在较特异的负相关。多元回归分析还显示，血清IL-6和TNF-α水平与血清谷甾醇水平呈显著负相关。当ABCG5/8KO小鼠和ABCG5/8杂交鼠给予高脂饲料时，我们观察到ABCG5/8 KO小鼠体重增加、脂肪肝改变和肾上腺周围脂肪组织的扩张受到抑制，而摄食量没有任何改变。我们还观察到ABCG5/8KO小鼠血浆IL-6和TNF-α水平，肝脏中TNF-α和PAI-1的表达，以及脂肪组织中IL-6、TNF-α和MCP-1的表达水平都较低。这些结果表明，谷甾醇可以抑制肥胖相关的慢性炎症，并可能适用于代谢性疾病的治疗。
The physiological roles of phytosterols in chronic inflammation, which are believed to be involved in the underlying mechanisms for metabolic diseases, have yet to be elucidated. Therefore, in the present study, we aimed to elucidate the physiological roles of phytosterols in both clinical studies and animal experiments. We observed the existence of rather specific negative correlations between the serum sitosterol level and the serum IL-6 and the TNF-alpha levels in both diabetic subjects (n = 46) and non-diabetic subjects (n = 178). Multiple regression analyses also revealed that the serum IL-6 and TNF-alpha levels exhibited strong negative correlations with the serum sitosterol levels. When ABCG5/8 KO mice with markedly elevated plasma sitosterol levels and ABCG5/8 hetero mice were fed a high-fat diet, we observed that the increase in body weight, the fatty liver changes, and the expansion of perigonadal adipose tissues were suppressed in ABCG5/8 KO mice without any modulation of food intake. We also observed that the plasma IL-6 and TNF-alpha levels, the expressions of TNF-alpha and PAI-1 in the liver and the expressions of the IL-6, TNF-alpha, and MCP-1 levels in the adipose tissue were lower in ABCG5/8 KO mice. These results suggest that sitosterol might suppress obesity-related chronic inflammation and might be applicable to the treatment of metabolic diseases.