RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.
RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.
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DOI：
10.1016/j.dnarep.2017.02.004
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发表时间：
2017-04
期刊：
影响因子：
3.8
通讯作者：
D'Argenio DZ
中科院分区：
文献类型：
--
作者：
Zhang Y;Hu K;Beumer JH;Bakkenist CJ;D'Argenio DZ
我们提出了一个全面的软件程序，RAD-ADAPT，在放射生物学克隆形成试验的定量分析。该软件建立了两种常用的克隆形成分析模型：线性二次模型和单击多靶点模型。RAD-ADAPT使用最大似然估计方法来获得参数估计值，假设细胞集落计数数据遵循Poisson分布。该程序具有直观的界面，可生成模型预测图，将模型参数估计值制成表格，并允许对不同组间的参数进行自动统计比较。RAD-ADAPT界面使用统计软件R编写，基础计算由ADAPT软件系统完成，用于药代动力学/药效学系统分析。RAD-ADAPT的使用是使用一个例子来证明的，该例子检查了电离辐射后药理学ATM和ATR激酶抑制对人肺癌细胞系A549的影响。
We present a comprehensive software program, RAD-ADAPT, for the quantitative analysis of clonogenic assays in radiation biology. Two commonly used models for clonogenic assay analysis, the linear-quadratic model and single-hit multi-target model, are built in the software. RAD-ADAPT uses maximum likelihood estimation method to obtain parameter estimates with the assumption that cell colony count data follow a Poisson distribution. The program has an intuitive interface, generates model prediction plots, tabulates model parameter estimates, and allows automatic statistical comparison of parameters between different groups. The RAD-ADAPT interface is written using the statistical software R and the underlying computations are accomplished by the ADAPT software system for pharmacokinetic/pharmacodynamic systems analysis. The use of RAD-ADAPT is demonstrated using an example that examines the impact of pharmacologic ATM and ATR kinase inhibition on human lung cancer cell line A549 after ionizing radiation.
DOI：
10.1016/j.mrfmmm.2011.01.005
发表时间：
2011-03-15
影响因子：
2.3
作者：
White, Jason S.;Yue, Ning;Hu, Jing;Bakkenist, Christopher J.
通讯作者：
Bakkenist, Christopher J.