Synthesis of (+)-Methyl Dihydropalustramate and of the Pyrido[1,2-a]azepine Core of Stemona Alkaloids
Synthesis of (+)-Methyl Dihydropalustramate and of the Pyrido[1,2-a]azepine Core of Stemona Alkaloids
复制标题
( )-二氢棕榈酸甲酯和百部生物碱吡啶并[1,2-a]氮杂核的合成
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T. Bach
中科院分区：
文献类型：
--
作者：
C. Mayer;A. Romek;T. Bach
Abstract Starting from a readily available, enantiomerically pure 2,6-disubstituted piperidine the synthesis of pyrido[1,2-a]azepines was accomplished. Key reactions for the ring closure were a photochemically induced acyl radical addition or a SmI2-promoted ketyl radical addition to an α,β-unsaturated ester. En route to the cyclization precursor an epoxidiation/ring opening sequence led to an undesired oxazolidinone which turned out to be useful for the configuration assignment. The compound was successfully converted into (+)-methyl dihydropalustramate.
