EXTINCTION OF EXPERIMENTAL MAMMARY CANCER, .1. ESTRADIOL-17BETA AND PROGESTERONE
EXTINCTION OF EXPERIMENTAL MAMMARY CANCER, .1. ESTRADIOL-17BETA AND PROGESTERONE
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DOI：
10.1073/pnas.48.3.379
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发表时间：
1962-01-01
影响因子：
11.1
通讯作者：
MORII, S
中科院分区：
文献类型：
--
作者：
HUGGINS, C;MOON, RC;MORII, S
A single feeding of 7,12-dimethylbenz(a)anthracene to rats induced mammary cancer. Hormone modifications which induced exuberant growth of normal mammary glands were furnished for a limited time in groups of animals which had been fed this hydrocarbon 15 days earlier. Pregnancy accelerated the growth of mammary cancers. Progesterone, alone, had a similar cancer-promoting effect in intact females. Estradiol-17[beta] delayed the appearance of cancer of the breast, and eventually 100% of the animals developed mammary cancer. Estradiol- 17[beta] administered concurrently with progesterone destroyed a significant number of mammary cancers; 52% of the rats treated with this combination of hormones apparently were free from cancer after six months. This is the extinction of cancer through hormone-interference with a steroid mechanism which is essential for the life of the malignant cell. Estradiol-17[beta] with progesterone induced extensive hyperplasia of normal mammary glands and did not destroy benign tumors of the breast or cancer of the ear duct. The combined administration of estradiol- 17[beta] and progesterone was not toxic, nor did it cause a long-continued depression of activity of the ovaries; normal ovarian function was restored promptly after cessation of 30-day hormone treatment.
