Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
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DOI：
10.1093/aje/152.6.514
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发表时间：
2000-09-15
影响因子：
5
通讯作者：
Hunter, DJ
中科院分区：
文献类型：
--
作者：
van den Brandt, PA;Spiegelman, D;Hunter, DJ
人体测量指数与乳腺癌风险之间的关联是使用七项前瞻性队列研究的合并数据分析的。这些队列共有337,819名妇女和4,385例入侵性乳腺癌病例。在控制生殖，饮食和其他危险因素的多元分析中，每5 cm的乳腺癌的相对风险（RR）为1.02（95％置信区间（CI）：0.96，1.10）在过后妇女和1.07）和1.07 （95％CI：1.03，1.12）在绝经后妇女中。体重指数（BMI）分别与绝经前和绝经后妇女的乳腺癌显着相关和正相关。这些关联是非线性的。与BMI小于21 kg/m（2）的绝经前女性相比，BMI超过31 kg/m（2）的女性的RR为0.54（95％CI：0.34，0.85）。在绝经后妇女中，当BMI超过28 kg/m时，RR并没有进一步增加（2）；这些女性的RR为1.26（95％CI：1.09，1.46）。作者几乎没有证据表明与其他乳腺癌危险因素相互作用。他们的数据表明，高度是绝经后乳腺癌的独立危险因素。在绝经前妇女中，这种关系尚不清楚。 BMI与乳腺癌之间的关联因绝经状态而异。体重控制可能会降低绝经后妇女的风险。
The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. in multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (CI): 0.96, 1.10) in premenopausal women and 1.07 (95% CI: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m(2), women with a BMI exceeding 31 kg/m(2) had an RR of 0.54 (95% CI: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m(2); the RR for these women was 1.26 (95% CI: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer Varies by menopausal status. Weight control may reduce the risk among postmenopausal women.