CA 19.9, CA 242 and CEA in the diagnosis and follow-up of pancreatic cancer
CA 19.9, CA 242 and CEA in the diagnosis and follow-up of pancreatic cancer
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DOI：
10.1177/172460089601100203
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发表时间：
1996-04-01
影响因子：
2
通讯作者：
Zerbi, A
中科院分区：
文献类型：
--
作者：
Banfi, G;Bravi, S;Zerbi, A
胰腺癌的诊断通常是在疾病的晚期，当预后很差时。我们在连续的42个胰腺猫电影中比较了CA19.9、CEA和新提出的粘蛋白CA 242的行为。对照组为21例良性胰腺疾病患者。在推荐的临界值（CA 19.9为37 U/ml，CA 242为20 U/ml，CEA为8 ng/ml）下，我们获得了CA 19.9的90%特异性和CA 242和CEA的85%特异性。CA19.9、CA 242和CEA的敏感性分别为85.7%、73.8%和26.2%。CA 19.9和CA 242在癌症的不同TNM分期以及Hermreck分类的III期和IV期中显示出相同的行为。此外，CA19.9和CA 242在存活期监测的10例疾病复发患者中表现出相同的行为。ROC曲线评价显示，CA 242与CA19.9非常相似，在10%以下的假阳性范围内，CA 242优于CA19.9，而在70%以上的真阳性范围内，CA19.9优于CA 242。CA 242可代替CA19.9诊断胰腺癌。
The diagnosis of pancreatic cancer is usually made in the advanced stages of the disease when the prognosis is poor. We compared the behavior of CA19.9, CEA and the newly proposed mucin CA242 in a consecutive series of 42 pancreatic cat-cinemas. A control group was recruited of 21 patients with benign pancreatic diseases. With the recommended cutoffs (37 U/ml for CA19.9, 20 U/ml for CA242 and 8 ng/ml for CEA) we obtained a specificity of 90% for CA19.9 and of 85% for CA242 and CEA. The sensitivity was 85.7% for CA19.9, 73.8% for CA242 and 26.2% for CEA. CA19.9 and CA242 showed identical behavior in various TNM stages of cancer and in stages III and IV of the Hermreck classification. Moreover; CA19.9 and CA242 shouted identical behavior in 10 patients monitored during the survival period who developed recurrence of disease. ROC curve evaluation demonstrated that CA242 and CA19.9 were very similar The results of CA242 were better than those of CA19.9 in the false positive range under 10%, whereas CA19.9 had a better performance in the true positive range over 70%. CA242 could be used instead of CA19.9 for diagnosing pancreatic carcinoma.