Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action.
Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action.
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DOI：
10.1155/2012/136937
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发表时间：
2012
影响因子：
2.2
通讯作者：
Lancha AH Jr
中科院分区：
文献类型：
--
作者：
Nicastro H;da Luz CR;Chaves DF;Bechara LR;Voltarelli VA;Rogero MM;Lancha AH Jr
骨骼肌蛋白质周转受细胞内信号通路的调节，这些信号通路涉及蛋白质的合成、降解和炎症。在癌症、衰老和脓毒症等病理条件下观察到的肌肉细胞的促炎状态，可以直接调节蛋白质翻译的启动和肌肉的蛋白质分解，从而导致蛋白质的负周转。在这种背景下，支链氨基酸(BCAA)，特别是亮氨酸，被描述为一种能够增强蛋白质翻译起始和减弱蛋白质降解的强烈营养刺激。此外，在炎症条件下，支链氨基酸可以转化为谷氨酸，以增加谷氨酰胺的合成，谷氨酰胺是炎症细胞(如巨噬细胞)高度消耗的底物。本文介绍了炎症在肌肉重塑中的作用，补充支链氨基酸在调节骨骼肌炎症状态中可能的代谢和细胞效应，以及对蛋白质合成和降解的影响。
Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.