Spatio-temporal patterns generated by Salmonella typhimurium.
Spatio-temporal patterns generated by Salmonella typhimurium.
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DOI：
10.1016/s0006-3495(95)80400-5
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发表时间：
1995-05
影响因子：
3.4
通讯作者：
D. Woodward;R. Tyson;M. Myerscough;James D. Murray;E. O. Budrene;H. Berg
中科院分区：
文献类型：
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作者：
D. Woodward;R. Tyson;M. Myerscough;James D. Murray;E. O. Budrene;H. Berg
我们目前的实验结果表明，细胞的趋化性菌株聚集在响应梯度的氨基酸，引诱剂，他们自己排泄的细菌鼠伤寒沙门氏菌。根据细胞培养的条件，它们形成连续或穿孔环的周期性阵列，这些环在扩展的细菌菌苔内依次出现。基于这些实验，我们开发了一个生物现实的细胞趋化性模型来描述细菌的自组织。模型机制的数值和分析研究表明，这两种类型的观察到的几何图案可以产生的细胞与它们产生的化学引诱物的相互作用。
We present experimental results on the bacterium Salmonella typhimurium which show that cells of chemotactic strains aggregate in response to gradients of amino acids, attractants that they themselves excrete. Depending on the conditions under which cells are cultured, they form periodic arrays of continuous or perforated rings, which arise sequentially within a spreading bacterial lawn. Based on these experiments, we develop a biologically realistic cell-chemotaxis model to describe the self-organization of bacteria. Numerical and analytical investigations of the model mechanism show how the two types of observed geometric patterns can be generated by the interaction of the cells with chemoattractant they produce.