Primate prefrontal neurons encode the association of paired visual stimuli during the pair-association task
Primate prefrontal neurons encode the association of paired visual stimuli during the pair-association task
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灵长类动物前额叶神经元在成对联想任务中编码成对视觉刺激的关联
DOI：
10.1016/j.bandc.2011.03.001
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发表时间：
2011
影响因子：
2.5
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Andreau;J.M. and Funahashi;S.
前额叶皮层（PFC）被认为有助于记忆过程，例如将表征编码到长期记忆（LTM）中并从LTM中检索这些表征。然而，全氟化学品对LTM过程的贡献的细节并不为人所知。为了研究PFC对LTM过程的贡献的特征，我们分析了猴子使用12对复杂的视觉图像执行配对关联（PA）任务时的单神经元活动。在60个神经元的样本期活动，32%的表现出最强和第二强的样本期活动时，一个特定的刺激对（对选择性）。此外，PFC的样本期活动的平均潜伏期为138ms，比ITC神经元在自下而上条件下的潜伏期长，但比自上而下条件下的潜伏期短。这些结果表明，PFC参与编码和检索信息的LTM过程中，对选择性的采样周期活动可能是一个候选人的自上而下的信号，PFC提供给ITC在检索信息从LTM。
The prefrontal cortex (PFC) is known to contribute to memory processes such as encoding representations into long-term-memory (LTM) and retrieving these representations from LTM. However, the details of the PFC’s contribution to LTM processes are not well known. To examine the characteristics of the PFC’s contribution to LTM processes, we analyzed single-neuron activity while monkeys performed a pair-association (PA) task using 12 pairs of complex visual images. Among 60 neurons with sample-period activity, 32% showed the strongest and second-strongest sample-period activities when a particular pair of stimuli was presented (pair selectivity). In addition, the mean latency of sample-period activity was 138ms in the PFC, which was longer than that observed in ITC neurons under bottom-up conditions, but shorter than that under top-down conditions. These results indicate that the PFC participates in encoding and retrieving information in LTM processes and that pair-selective sample-period activity might be a candidate for the top-down signal that the PFC provides to the ITC during the retrieval of information from LTM.