The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia
The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia
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DOI：
10.1016/j.neulet.2005.08.019
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发表时间：
2005-12-30
影响因子：
2.5
通讯作者：
Kuroda, S
中科院分区：
文献类型：
--
作者：
Otani, K;Ujike, H;Kuroda, S
锌指和含DHHC结构域的蛋白8（ZDHHC 8）基因位于染色体22 q11上，多次基因组扫描提供了与双相情感障碍（BPD）和精神分裂症显着联系的重复证据。最近的一项研究显示，ZDHHC 8基因内含子4中的单核苷酸多态性（SNP）rs 175174与美国和南非精神分裂症患者的易感性相关，该SNP对剪接具有潜在影响。我们通过病例-对照研究，在日本BPD患者（N=172）和对照组（N=298）或精神分裂症患者（N=407）和对照组（N = 497）中检测了ZDHHC 8基因的三个SNP，包括rs 175174。未观察到与BPD或精神分裂症的显著关联。按亚类、双相I型和双相II型BPD、偏执型和紊乱型精神分裂症分层后，未发现显著相关性，按性别划分后，也未发现与任何一种疾病的显著相关性。这些数据表明，ZDHHC 8基因可能与BPD或精神分裂症的易感性无关，至少在日本人群中是这样。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
The zinc finger and DHHC domain-containing protein 8 (ZDHHC8) gene is located on chromosome 22q11, which several genome scans have provided repeated evidence for a significant linkage with bipolar disorder (BPD) and schizophrenia. A recent study revealed that a single nucleotide polymorphism (SNP), rs175174, which has potential effects on splicing, in intron 4 of the ZDHHC8 gene is associated with susceptibility to patients with schizophrenia in US and South Africa. We examined three SNPs of the ZDHHC8 gene, including rs175174, by case-control association in Japanese patients with BPD (N=172) and controls (N=298) or patients with schizophrenia (N=407) and controls (N=497). No significant association with BPD or schizophrenia was observed. After stratification by subcategories, bipolar I and II of BPD, and paranoid and disorganized types of schizophrenia, no significant association was found, nor was a significant association with either disorder found after dividing by gender. These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population. (C) 2005 Elsevier Ireland Ltd. All rights reserved.