Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes
Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes
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DOI：
10.1016/s0047-6374(03)00028-9
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发表时间：
2003-04-01
影响因子：
5.3
通讯作者：
Gollapudi, S
中科院分区：
文献类型：
--
作者：
Gupta, S;Chiplunkar, S;Gollapudi, S
人类的衰老与T细胞数量和功能的进行性下降有关。此外，在人类衰老过程中，肿瘤坏死因子-α(TNF-α)的产生也会增加。肿瘤坏死因子-α既介导生存信号，也介导细胞死亡信号。肿瘤坏死因子-α通过TNFR-I和TNFR-II发挥其生物学效应。在这里，我们讨论了由肿瘤坏死因子-α诱导的信号通路，以及年龄对肿瘤坏死因子-α诱导的T细胞及其亚群凋亡的影响。来自老年人的T细胞和T细胞亚群对肿瘤坏死因子-α诱导的细胞凋亡更敏感，这似乎是由于凋亡信号增加和生存信号减少所致。(C)2003爱思唯尔爱尔兰科学有限公司。保留所有权利。
Aging in humans is associated with progressing decline in T cell numbers and functions. In addition, there is an increased production of tumor necrosis factor-alpha (TNF-alpha) during human aging. TNF-alpha mediates both survival and cell death signals. TNF-alpha exerts its biological effects via TNFR-I and TNFR-II. Here we discuss signaling pathways induced by TNF-alpha and the effect of age on TNF-alpha-induced apoptosis in T cells and T cell subsets. T cells and T cell subsets from aged humans are more sensitive to TNF-alpha-induced apoptosis, which appears to be due to both an increased apoptotic signaling and decreased survival signals. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.