The later part of high-frequency oscillations in human somatosensory evoked potentials is enhanced in aged subjects
The later part of high-frequency oscillations in human somatosensory evoked potentials is enhanced in aged subjects
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DOI：
10.1016/s0304-3940(99)00811-3
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发表时间：
1999-12-03
影响因子：
2.5
通讯作者：
Hashimoto, I
中科院分区：
文献类型：
--
作者：
Nakano, S;Hashimoto, I
在正中神经刺激后，300-900 Hz范围内的高频振荡（HFO）已被证明与人类躯体感觉皮层的初级反应（N20）同时发生。我们研究了年龄对体感诱发HFO的影响。本文报道了15例正常青年人和15例正常老年人在电刺激右侧正中神经后，用滤波器在10-2000 Hz范围内记录体感诱发电位（SEP）。通过使用300-900 Hz的带通对宽带SEP（10-2000 Hz）进行数字滤波来获得HFO。在老年受试者中，N20峰与HFO终点之间的HFO负峰数、振幅、持续时间和面积均显著大于年轻受试者。然而，N20起始和N20峰值之间的那些在组间没有差异。这些结果表明，HFO的后期与衰老有关。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
High-frequency oscillations (HFOs) in the range of 300-900 Hz have been shown to occur simultaneously with the primary response (N20) of the human somatosensory cortex following median nerve stimulation. We studied the effects of aging on somatosensory evoked HFOs. Somatosensory evoked potentials (SEPs) were recorded with a filter set at 10-2000 Hz following right median nerve stimulation in 15 normal young subjects and 15 normal aged subjects. The HFOs were obtained by digitally filtering the wide-band SEPs (10-2000 Hz) using a band-pass of 300-900 Hz. In the aged subjects, the number of negative peaks, amplitudes, duration and area of the HFOs between N20 peak and HFO endpoint were significantly larger than those of young subjects. However, those between N20 onset and N20 peak did not differ between the groups. These results suggest that the later part of HFOs is associated with aging. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.