Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
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胰岛中的 Frataxin 缺乏会因 β 细胞质量的损失而导致糖尿病。
DOI：
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发表时间：
2003
影响因子：
15.9
通讯作者：
A. Pfeiffer
中科院分区：
文献类型：
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作者：
M. Ristow;H. Mulder;D. Pomplun;T. Schulz;Katrin Müller;Anja Krause;M. Fex;H. Puccio;Jörg Müller;F. Isken;J. Spranger;D. Müller;M. Magnuson;M. Möhlig;M. Koenig;A. Pfeiffer
糖尿病是由产生胰岛素的β细胞绝对(1型)或相对(2型)缺乏引起的。我们选择性地干扰了胰岛β细胞中线粒体蛋白Frataxin的表达。小鼠出生时是健康的，但随后发展为糖耐量受损，进展为明显的糖尿病。这些观察结果可以用基因敲除动物的β细胞团丢失导致的胰岛素分泌障碍来解释。在这种表型之前，基因敲除的胰岛中的活性氧水平升高，细胞凋亡的频率增加，增殖的β细胞数量减少。因此，胰腺β细胞中Frataxin基因的破坏会导致细胞生长停滞和细胞凋亡后的糖尿病，同时胰岛中的活性氧物种增加。这些观察可能为深入了解人类不同亚型糖尿病中观察到的β细胞功能恶化提供洞察力。
Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic beta cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. These observations were explained by impairment of insulin secretion due to a loss of beta cell mass in knockout animals. This phenotype was preceded by elevated levels of reactive oxygen species in knockout islets, an increased frequency of apoptosis, and a decreased number of proliferating beta cells. Hence, disruption of the frataxin gene in pancreatic beta cells causes diabetes following cellular growth arrest and apoptosis, paralleled by an increase in reactive oxygen species in islets. These observations might provide insight into the deterioration of beta cell function observed in different subtypes of diabetes in humans.
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影响因子：
7.7
作者：
A. Butler;J. Janson;S. Bonner-Weir;R. Ritzel;R. Rizza;P. Butler
通讯作者：
A. Butler;J. Janson;S. Bonner-Weir;R. Ritzel;R. Rizza;P. Butler
DOI：
10.1073/pnas.220403797
发表时间：
2000-10-24
影响因子：
11.1
作者：
Ristow, M;Pfister, MF;Kahn, CR
通讯作者：
Kahn, CR
影响因子：
3.3
作者：
Ke, LD;Chen, Z;Yung, WKA
通讯作者：
Yung, WKA
影响因子：
7.7
作者：
Laybutt, DR;Kaneto, H;Weir, GC
通讯作者：
Weir, GC