Current Use for Old Antibacterial Agents: Polymyxins, Rifamycins, and Aminoglycosides
Current Use for Old Antibacterial Agents: Polymyxins, Rifamycins, and Aminoglycosides
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DOI：
10.1016/j.idc.2009.06.004
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发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Kaye, Donald
中科院分区：
文献类型：
--
作者：
Chen, Luke F.;Kaye, Donald
本文回顾了三类抗菌药物，它们在细菌感染中不常用，因此可以被认为是特殊用途的药物。多粘菌素专门用于对几乎所有其他类别的药物具有耐药性的革兰氏阴性杆菌。利福平用于治疗，偶尔作为治疗难治性革兰氏阳性球菌感染的伴随药物，尤其是涉及异物的感染。利福昔明是一种新型利福霉素，是一种严格的肠道抗生素，被批准用于治疗旅行者腹泻，并有望成为治疗难治性艰难梭菌感染的药物。氨基糖苷类药物主要用作治疗耐药革兰氏阴性杆菌感染和革兰氏阳性球菌性心内膜炎的伴随药物。
This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infections, especially those involving foreign bodies. Rifaximin is a new rifamycin that is a strict enteric antibiotic approved for treatment of traveler's diarrhea and is showing promise as a possible agent for refractory Clostridium difficile infections. The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis.