Veganism and its relationship with insulin resistance and intramyocellular lipid
Veganism and its relationship with insulin resistance and intramyocellular lipid
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DOI：
10.1038/sj.ejcn.1602076
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发表时间：
2005-02-01
影响因子：
4.7
通讯作者：
Frost, GS
中科院分区：
文献类型：
--
作者：
Goff, LM;Bell, JD;Frost, GS
设计：病例对照研究。地点：英国伦敦Hammersmith医院校园帝国理工学院医学院。研究对象：共有24名素食者和25名杂食者参与本研究，其中3名素食者不匹配，因此21名素食者和25名杂食者的匹配结果显示。受试者在性别、年龄和体重指数(BMI)方面进行匹配。干预：获得全面的人体测量、7天的饮食评估和体力活动水平。用稳态模型评估法(HOMA)测定胰岛素敏感性(%S)和β细胞功能(%B)。结果：两组在性别、年龄、BMI、腰围、体脂百分比、活动量、能量摄入量等方面无明显差异。纯素食者的收缩压显著低于对照组(-11.0 mm Hg，CI-20.6~-1.3，P=0.027)，碳水化合物(10.7%，CI 6.8~14.5，P<；0.001)、非淀粉多糖(20.7g，CI 15.8~25.6，P<；；0.001)和多不饱和脂肪(2.8%，CI 1.0~4.6，P=0.003)，血糖指数显著降低(-3.7，CI-6.7~-0.7，P=0.01)。此外，纯素食者的空腹血浆三酰甘油(-0.7mmoL/L，CI-0.90~-0.4P<；0.001)和血糖(-0.4mmoL/L，CI-0.70~-0.09，P=0.05)浓度较低。比目鱼肌组织中IMCL水平显著降低(-9.7，CI-16.2~-3.3，P=0.0 1)。结论：纯素食者的食物摄入量和生化指标具有心脏保护作用，IMCL蓄积和β细胞保护作用较低。
Objective: To test the hypothesis that dietary factors in the vegan diet lead to improved insulin sensitivity and lower intramyocellular lipid (IMCL) storage.Design: Case-control study.Setting: Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK.Subjects: A total of 24 vegans and 25 omnivores participated in this study; three vegan subjects could not be matched therefore the matched results are shown for 21 vegans and 25 omnivores. The subjects were matched for gender, age and body mass index (BMI).Interventions: Full anthropometry, 7-day dietary assessment and physical activity levels were obtained. Insulin sensitivity (%S) and beta-cell function (%B) were determined using the homeostatic model assessment (HOMA). IMCL levels were determined using in vivo proton magnetic resonance spectroscopy; total body fat content was assessed by bioelectrical impedance.Results: There was no difference between the groups in sex, age, BMI, waist measurement, percentage body fat, activity levels and energy intake. Vegans had a significantly lower systolic blood pressure (-11.0 mmHg, CI -20.6 to -1.3, P = 0.027) and higher dietary intake of carbohydrate (10.7%, CI 6.8-14.5, P < 0.001), nonstarch polysaccharides (20.7 g, CI 15.8-25.6, P < 0.001) and polyunsaturated fat (2.8%, CI 1.0-4.6, P = 0.003), with a significantly lower glycaemic index (-3.7, CI -6.7 to -0.7, P = 0.01). Also, vegans had lower fasting plasma triacylglycerol (-0.7 mmol/l, CI -0.9 to -0.4, P < 0.001) and glucose (-0.4 mmol/l, CI -0.7 to -0.09, P = 0.05) concentrations. There was no significant difference in HOMA%S but there was with HOMA%B (32.1%, CI 10.3-53.9, P = 0.005), while IMCL levels were significantly lower in the soleus muscle (-9.7, CI -16.2 to -3.3, P = 0.01).Conclusion: Vegans have a food intake and a biochemical profile that will be expected to be cardioprotective, with lower IMCL accumulation and beta-cell protective.