Dopaminergic involvement in activational aspects of motivation: Effects of haloperidol on schedule-induced activity, feeding, and foraging in rats
Dopaminergic involvement in activational aspects of motivation: Effects of haloperidol on schedule-induced activity, feeding, and foraging in rats
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多巴胺能参与动机的激活方面：氟哌啶醇对大鼠日程诱导的活动、进食和觅食的影响
DOI：
10.3758/bf03327307
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
J. Salamone
中科院分区：
文献类型：
--
作者：
J. Salamone
多巴胺拮抗剂氟哌啶醇(HP)降低了周期性向缺乏食物的大鼠提供食物所诱导的运动活动，随着剂量的增加，活动在30分钟的测试过程中显著下降。然而，HP处理的大鼠继续食用所有的食物颗粒，1只被直接观察的大鼠继续保持在食物盘附近。惠普还扰乱了半自然环境中的觅食和食物摄取。除了减少食物摄入量，惠普还减少了平均进食持续时间，增加了总进食次数。这些结果表明，尽管惠普在这些任务中干扰了食物动机行为的激活方面，但接受惠普治疗的受试者继续指导食物获取和消费的行为。
The dopamine antagonist haloperidol (HP) decreased motor activity that was induced by periodic presentation of food to food-deprived rats, with the higher doses leading to a marked decline in activity across the 30-min test session. However, HP-treated rats continued to consume all the food pellets, and 1 rat that was directly observed continued to remain in proximity to the food dish. HP also disrupted foraging and food intake in a seminaturalistic environment. In addition to decreasing food intake, HP decreased the average duration, and increased the total number, of feeding bouts. These results indicate that although HP disrupted the activational aspects of food-motivated behavior in these tasks, HP-treated subjects continued to direct behavior toward food acquisition and consumption.