Computational analysis of flow in a curved tube model of the coronary arteries: Effects of time-varying curvature
Computational analysis of flow in a curved tube model of the coronary arteries: Effects of time-varying curvature
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DOI：
10.1114/1.113
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发表时间：
1998-11-01
影响因子：
3.8
通讯作者：
Moore, JE
中科院分区：
文献类型：
--
作者：
Santamarina, A;Weydahl, E;Moore, JE
为了更好地了解冠状动脉的血流模式，研究了曲率半径随时间变化的弯曲管的血流。利用市售软件建立了计算流模型。动脉模型具有均匀的圆形截面，并且假设曲率沿管和在一个平面上是恒定的。利用动态相似的体外实验装置对计算模型进行了验证。在入口处规定了雷诺数为300的稳定匀速。得到了两组结果：一组结果是曲率在曲率的平均值、最大值和最小半径处保持不变（准静态），另一组结果是曲率以1hz的频率随时间呈正弦变化（动态）。动态分析结果表明，在距离进口10个管径的范围内，壁面剪切速率的变化幅度可达静态平均壁面剪切速率的52%。动态分析的结果在准静态预测的6%以内。变形几何的真实建模对于确定冠状动脉中哪些位置受到低和振荡壁剪切应力，与动脉粥样硬化相关的血流模式非常重要。(C) 1998生物医学工程学会。[s0090 - 6964(98) 00306 - 3]。
The flow through a curved tube whose radius of curvature varies with time was studied in order to better understand flow patterns in coronary arteries. A computational flow model was constructed using commercially available software. The artery model featured a uniform circular cross section, and the curvature was assumed to be constant along the tube, and in one plane. The computational model was verified with the use of a dynamically similar in vitro apparatus. A steady uniform velocity was prescribed at the entrance at a Reynolds number of 300. Two sets of results were obtained: one in which the curvature was held constant at the mean, maximum and minimum radii of curvature (quasistatic), and another in which the curvature was varied sinusoidally in time at a frequency of 1 Hz (dynamic). The results of the dynamic analysis showed that the wall shear rates varied as much as 52% of the static mean wall shear rate within a region of 10 tube diameters from the inlet. The results of the dynamic analysis were within 6% of the quasistatic predictions. Realistic modeling of the deforming geometry is important in determining which locations in the coronary arteries are subjected to low and oscillating wall shear stresses, flow patterns that have been associated with atherogenesis. (C) 1998 Biomedical Engineering Society. [S0090-6964(98)00306-3].