Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23.
Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23.
复制标题
作者：
孤立的淋巴滤泡（ILF）出生后在小肠和大肠（SI和LI）中发育，代表肠道免疫系统对微生物群的动态反应。尽管它们有相似之处，但SI和LI的ILF发展在许多层面上有所不同。我们表明，与SI中的ILF不同，微生物群抑制结肠中的ILF发展，因为无菌小鼠的常规化减少了结肠ILF。由此，我们确定了一种新的机制，调节结肠ILF的发展，通过白细胞介素（IL）-25对IL-23的作用和它的能力，调节T调节细胞（Treg）分化。结肠ILF在缺乏其SI对应物发展所需的许多因子的情况下发展，并且可以被IL-25以外的因子特异性抑制。然而，IL-23是唯一确定的特异性促进结肠ILF而不影响SI-ILF发展的因子。IL-23和ILF都与炎症性肠病相关，这表明对该途径的破坏可能在微生物免疫稳态的破坏中起重要作用。
Isolated lymphoid follicles (ILFs) develop after birth in the small and large intestines (SI and LI) and represent a dynamic response of the gut immune system to the microbiota. Despite their similarities, ILF development in the SI and LI differs on a number of levels. We show that unlike ILF in the SI, the microbiota inhibits ILF development in the colon as conventionalization of germ-free mice reduced colonic ILFs. From this, we identified a novel mechanism regulating colonic ILF development through the action of interleukin (IL)-25 on IL-23 and its ability to modulate T regulatory cell (Treg) differentiation. Colonic ILF develop in the absence of a number of factors required for the development of their SI counterparts and can be specifically suppressed by factors other than IL-25. However, IL-23 is the only factor identified that specifically promotes colonic ILFs without affecting SI-ILF development. Both IL-23 and ILFs are associated with inflammatory bowel disease, suggesting that disruption to this pathway may have an important role in the breakdown of microbiota-immune homeostasis.
登录
查看更多内容
树突状细胞对于维持流感病毒感染小鼠肺部的三级淋巴结构至关重要。
DOI：
10.1084/jem.20090410
发表时间：
2009-10-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
GeurtsvanKessel CH;Willart MA;Bergen IM;van Rijt LS;Muskens F;Elewaut D;Osterhaus AD;Hendriks R;Rimmelzwaan GF;Lambrecht BN
通讯作者：
Lambrecht BN
DOI：
10.1084/jem.184.4.1449
发表时间：
1996-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1186/1742-4933-8-1
发表时间：
2011-01-07
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
McDonald KG;Leach MR;Huang C;Wang C;Newberry RD
通讯作者：
Newberry RD
影响因子：
6
作者：
Leithaeuser, Frank;Meinhardt-Krajina, Tamara;Reimann, Joerg
通讯作者：
Reimann, Joerg
DOI：
10.1084/jem.20100052
发表时间：
2011-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lochner M;Ohnmacht C;Presley L;Bruhns P;Si-Tahar M;Sawa S;Eberl G
通讯作者：
Eberl G