Prevention of chronic kidney disease: A global challenge
Prevention of chronic kidney disease: A global challenge
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DOI：
10.1111/j.1523-1755.2005.09802.x
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发表时间：
2005-09-01
影响因子：
19.6
通讯作者：
EL Nahas, AM
中科院分区：
文献类型：
--
作者：
Bello, AK;Nwankwo, E;EL Nahas, AM
鉴于世界范围内每年需要肾脏替代治疗（RRT）的患者数量不断增加，在过去二十年中，人们的注意力集中在满足终末期肾衰竭（ESRF）患者的医疗保健需求上。最近，随着慢性肾脏疾病（CKD）负担的增加，以及很大比例的人群受到早期CKD的影响，人们越来越意识到慢性肾脏疾病（CKD）的负担，并将注意力和医疗保健重点转移到CKD的预防和早期发现上。本文讨论了与一般人群以及有针对性的筛查相关的问题，倾向于后者。报告还审查了发展中国家和发达国家采取的一些筛查举措。它还强调了蛋白尿、慢性肾病和心血管疾病（CVD）之间的联系，因为越来越多的研究确定蛋白尿/蛋白尿以及慢性肾病是CVD的主要标志物。最后，简要回顾CKD的主要和次要干预策略及其实施的相关问题：人力和资金。
In view of the increasing number of patients requiring renal replacement therapy (RRT) every year worldwide, attention has focused over the last two decades on meeting the health care need of patients with end-stage renal failure (ESRF). More recently, increasing awareness of the growing burden of chronic kidney disease (CKD), with a large percentage of the population affected by early stages of CKD, has shifted attention and health care priority to the prevention and early detection of CKD. This article addresses issues related to general population as well as targeted screening, favoring the latter. It also examines some of the screening initiatives undertaken in both the developing and developed worlds. It also highlights the links between albuminuria, CKD, and cardiovascular disease (CVD) as an increasing number of studies identify albuminuria/proteinuria, as well as CKD as major markers of CVD. Finally, a brief review is included of primary and secondary intervention strategies for CKD and issues related to their implementation: manpower and funding.